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Bosentan is undoubtedly an inducer of CYP3A and CYP2C9. As a result plasma concentrations of medicine metabolized by both of these isozymes are going to be lowered when bosentan is coadministered.Bosentan and Ro forty eight-5033 are actually demonstrated for being substrates of your human organic and natural anion transporting polypeptides OATP1B1